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Ny forskning: Mangel på D-vitamin den altoverskyggende årsag til kræft

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#21 Antaeus



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Indsendt 5. juli 2007 - 21:22

ok. vidste godt at d-vitamin var knyttet til osteoporose m.m., men det nye er at RCT's viser effekt af d-vitamin til cancer. Mit spørgsmål var om der findes andre RCT's med effekt af d-vitamin mod cancer. Artiklen refererer til et studie der ikke viste samme (men dog nogen) effekt af 400iu d-vitamin.

Ja, det er nyt når vi taler RCT's. Epidemiologisk har man kendt resultaterne et stykke tid.
Jeg foretog en hurtig søgning i Medline og fandt en positiv undersøgelse, som du kan finde som fuld pdf-kopi i nedenstående link. Ellers er det jo bare om Pubmed og søge på hvad der er.
På colon cancer findes der to stk. større RCT's som ikke finder effekt. Bl.a. en publiceret i NEJM i 2006.

Artikel - adenoma - vitamin D + Calcium

Og her er nogle af de nyeste review på cancer - bl.a. et i Ugeskrift for Læger 2007.

Nutr Clin Pract. 2007 Jun;22(3):305-22. Related Articles, Links

Vitamin d and its role in cancer and immunity: a prescription for sunlight.

Mullin GE, Dobs A.

Integrative GI Nutrition Services, Capsule Endoscopy, Division of Gastroenterology and Liver Disease, Johns Hopkins Hospital, Baltimore, Maryland 21205, USA. gmullin1@jhmi.edu

Vitamin D has been recognized for more than a century as essential for the normal development and mineralization of a healthy skeleton. More extensive roles for vitamin D were suggested by the discovery of the vitamin D receptor (VDR) in tissues that are not involved in calcium and phosphate metabolism. VDR has been discovered in most tissues and cells in the body and is able to elicit a wide variety of biologic responses. These observations have been the impetus for a reevaluation of the physiologic and pharmacologic actions of vitamin D. Here, we review the role of vitamin D in regulation of the immune system and its possible role in the prevention and treatment of cancer and immune-mediated diseases.

Publication Types:
Research Support, N.I.H., Extramural

PMID: 17507731 [PubMed - indexed for MEDLINE]--------------------------------------------------------------------------------

2: Ugeskr Laeger. 2007 Apr 2;169(14):1299-302. Related Articles, Links

[Vitamin D and breast cancer]

[Article in Danish]

Nielsen LR, Mosekilde L.

Arhus Universitetshospital, Arhus Sygehus, Medicinsk-endokrinologisk Afdeling C. rejnmark@post6.tele.dk

Active vitamin D increases the differentiation and exerts antiproliferative effects in cancer cells. Recent data suggest that vitamin D is activated locally in cancer cells. Ecologic studies have shown an inverse correlation between breast cancer mortality and sun exposure and dietary vitamin D intake. In clinical studies an impaired vitamin D status is associated with a 20-30% increased breast cancer incidence and 10-20% increased mortality. As vitamin D insufficiency is common, it is important to clarify whether vitamin D status affects the risk and prognosis of breast cancer.

Publication Types:
English Abstract

PMID: 17437690 [PubMed - indexed for MEDLINE]


3: Br J Nutr. 2007 Apr;97(4):611-6. Related Articles, Links

Comment in:
Br J Nutr. 2007 Apr;97(4):596-7.

Calcium intake and vitamin D metabolism and action, in healthy conditions and in prostate cancer.

Bonjour JP, Chevalley T, Fardellone P.

Division of Bone Diseases (World Health Organization Collaborating Centre for Osteoporosis Prevention), Department of Rehabilitation and Geriatrics, University Hospitals of Geneva, Geneva 14, Switzerland. jean-philippe.bonjour@medecine.unige.ch

An association between Ca intake and the risk of prostate cancer has been reported in some but not all epidemiological studies. Assuming that a pathophysiological relationship would underlie this association, a favoured hypothesis proposes that relatively high Ca consumption could promote prostate cancer by reducing the production of 1,25-dihydroxyvitamin D (1,25(OH)2D; calcitriol), the hormonal form of vitamin D. The present review analyses the plausibility of this hypothesis by considering the quantitative relationships linking Ca intake to 1,25(OH)2D production and action in healthy conditions and in prostate cancer. Changes in the plasma level of 1,25(OH)2D in response to Ca intake are of very small magnitude as compared with the variations required to influence the proliferation and differentiation of prostate cancer cells. In most studies, 1,25(OH)2D plasma level was not found to be reduced in patients with prostate cancer. The possibility that the level of 1,25(OH)2D in prostate cells is decreased with a high-Ca diet has not been documented. Furthermore, a recent randomised placebo-controlled trial did not indicate that Ca supplementation increases the relative risk of prostate cancer in men. In conclusion, the existence of a pathophysiological link between relatively high Ca intake and consequent low production and circulation level of 1,25(OH)2D that might promote the development of prostate cancer in men remains so far an hypothesis, the plausibility of which is not supported by the analysis of available clinical data.

Publication Types:

PMID: 17349071 [PubMed - indexed for MEDLINE]


4: Int J Biochem Cell Biol. 2007;39(4):672-7. Epub 2006 Nov 3. Related Articles, Links

Colorectal cancer: potential therapeutic benefits of Vitamin D.

Jiménez-Lara AM.

Department of Gene Expression Regulation, Instituto de Investigaciones Biomédicas Alberto Sols/Consejo Superior de Investigaciones Científicas/Universidad Autónoma de Madrid, C/Arturo Duperier 4, E-28029 Madrid, Spain. amjimenez@iib.uam.es

Colorectal cancer is a disease that originates from the neoplastic transformation of epithelial cells of the colon and rectum, as a result of the accumulation of genetic and epigenetic aberrations. At least four sequential genetic changes, affecting one oncogene (KRAS) and three tumor suppressor genes (APC, SMAD4 and TP53), are required for the development of colorectal cancer. Abundant experimental studies and epidemiological data, as well as several human clinical trials suggest a protective effect of Vitamin D against colon carcinogenesis. Hypercalcemia, a side effect of natural Vitamin D, has currently restricted its therapeutic use; however, the development of new synthetic analogs with reduced hypercalcemic activity is promising for cancer therapy and prevention. Extensive research to elucidate the mechanisms underlying the anti-cancer action of Vitamin D is being undertaken. Understanding the complex molecular and cellular networks induced by Vitamin D or its analogs will improve the use of these compounds for the prevention and treatment of colorectal cancer.

Publication Types:
Research Support, Non-U.S. Gov't

PMID: 17157547 [PubMed - indexed for MEDLINE]


5: Recent Results Cancer Res. 2007;174:197-204. Related Articles, Links

Vitamin D--an emerging issue in skin cancer control. Implications for public health practice based on the Australian experience.

Sinclair C.

The Cancer Council Victoria, Carlton, Australia.

Over recent years, the evidence has been accumulating that vitamin D has a positive impact on our health. This is likely to have an impact on the future of our public health advice related to skin cancer prevention. This paper explores, from a public health perspective based on Australian experience, how skin cancer prevention messages need to be managed in light of new information about vitamin D and in particular, the times when sun protection advice should be provided. Conclusions are drawn in relation to how the vitamin D message can be complementary to the sun protection message and explores what health practitioners should do in light of artificial tanning sunbeds being a potential source of vitamin D.

Publication Types:

PMID: 17302197 [PubMed - indexed for MEDLINE]


6: Curr Opin Clin Nutr Metab Care. 2007 Jan;10(1):6-11. Related Articles, Links

Vitamin D status and cancer: new insights.

Schwartz GG, Skinner HG.

Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. gschwart@wfubmc.edu

PURPOSE OF REVIEW: The aim of this article is to describe recent developments in human studies of the role of vitamin D in the etiology and treatment of cancer. RECENT FINDINGS: Epidemiologic studies over the past year lend additional support for important roles for vitamin D in the natural history of several cancers. Studies showing risk reduction by vitamin D in prostate, colon and breast cancers were joined by new analyses of endometrial, skin, and pancreatic cancers. Interest in vitamin D has extended to examinations of its influence on premalignant conditions such as adenomatous polyps and breast density. Studies of vitamin D and cancer survival have featured prominently in the recent literature. Sun exposure and indicators of high vitamin D status were found to be associated with improved survival for cutaneous melanoma, Hodgkin's lymphoma, and cancers of the lung, breast, prostate and colon. Therapeutic trials of vitamin D are especially prominent in the treatment of prostate cancer. SUMMARY: Studies over the past year indicate potentially important roles for vitamin D in cancer prevention, survival and treatment.

Publication Types:

PMID: 17143048 [PubMed - indexed for MEDLINE]

Mennesket skabte Gud, Zorglub og Julemanden.


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