Theanin tilskud!

[Sqwii]

Hej!

Nogle af jer, som kender en del til Theanin?

Dette skulle være en aminosyre i grøn og sort te, som skal være godt imod:

- Stress

- PMS Symptomer

- Kræft

- Kolesterol (gør det lavere, de dårlige og højere de gode)

- Indlæringsevne og hukommelse

- Fedtforbræning

- Hypertension

- Styrker immunforsvaret markant

Hvis nogle er interesseret I at vide mere om dette produkt, så læs videre :

Theanine may have both mood-enhancing and nootropic properties. In human studies, oral administration of theanine has been reported to dose-dependently increase the production of alpha waves in the occipital and parietal regions of the brain [6-8]. According to one article, this signifies a state of being awake, alert, and relaxed at the same time. This effect occurs within 30-40 minutes of oral administration of 50-200 mg. It should be noted that the study population in this research consisted only of females 18-22 years of age, and this effect has not yet been confirmed in other human populations [8].

The behavioral effects of theanine on rodents have also been the subject of study. Theanine does not change activity level or exploration behavior in normal animals. However, it does improve performance on a number of tests of memory and learning, including the active avoidance test, the passive avoidance test, and the Morris water maze [9]. Using electroencephalography, it has also been determined that theanine antagonizes the effect of caffeine. If about eight times as much theanine than caffeine is given (on a per milligram basis), the effect of caffeine is completely blunted [2, 10]. It has been suggested that theanine is responsible for the relaxing effect of tea despite the caffeine content.

Animal studies have also explored the possible mechanism by which theanine leads to these effects. Theanine reliably causes a significant increase in CNS dopamine (DA) levels, especially in the striatum, hypothalamus, and hippocampus [2, 9, 11-12]. The effect theanine has on levels of other neurotransmitters is less well-established. It has been reported to both increase and decrease central serotonin levels [11-12]. One study indicated that it may decrease central norepinephrine [3]. Finally, a study in the early 70's reported that theanine may have an effect on the formation of gamma-aminobutyric acid (GABA) [13]. The direct mechanism for these changes is not clear, although it may be related to an effect at N-methyl-D-aspartate (NMDA) receptors [14].

Neuroprotection

Theanine has neuroprotective properties in experimental models. It has been found to reduce brain damage caused by middle cerebral artery (MCA) occlusion in mice and inhibit neuronal death caused by ischemia in gerbils, confirming the effects of many studies showing it to prevent neurotoxicity in vitro [11, 15]. Theanine is thought to be one of the reasons for the lower incidence of stroke in tea drinkers [11], and it has been suggested as a possible candidate for the treatment and prevention of stroke [2, 15]. In animals, theanine has also been reported to increase the synthesis rate of nerve growth factor (NGF) [6].

The neuroprotective properties are thought to be primarily due to the fact that it is structurally similar to glutamate. Glutamate is an excitatory neurotransmitter, and in some instances it can cause excitotoxicity [14]. It has been traditionally thought that theanine prevents toxicity by acting as a competitive antagonist to glutamate at ionotropic glutamate receptors, of which there are three types, NMDA, alpha-amino-3-hydroxy-5-methylisoxazol-4-propionic acid (AMPA), and kainate (KA) [15]. In rat cortical neurons, theanine acted at all three subtypes, but had less binding affinity than glutamate. Also, the binding affinity to NMDA receptors was an order of magnitude lower than to AMPA and KA receptors [14]. It is possible that actions at all of the subtypes could play important roles in the activity of theanine. It is known that AMPA receptor antagonists protect against ischemia caused by MCA occlusion in gerbils and rats and improve spatial memory in rats subjected to repeated ischemia, and the neuroprotective effect of AMPA and NMDA antagonists can be additive [15]. Also, another competitive NMDA antagonist prevented theanine-induced neurotransmitter release. Finally, theanine prevents neuronal death from kainate injection [14].

Because the effective concentration in antagonizing ionotropic glutamate receptors is so low compared to glutamate, a more recent study hypothesized that the neuroprotective effect was related to an effect at metabotropic glutamate receptors instead [11]. This study found that inhibition of glutamate-induced neuronal death by theanine could be inhibited by an antagonist of group I metabotropic glutamate receptors. This indicates that this may be the mechanism for the neuroprotective effect of theanine. Given the current state of research, it is too early to draw any solid conclusions, as the effect of theanine could ultimately prove to be due to an action at any combination of these receptors. An effect on glutamate transporters may also be involved [14].

A final mechanism of neuroprotection is the antioxidant effect of theanine. One study suggested that one of the protective mechanisms was inhibition of lipid peroxidation. Vitamin E has also been found to inhibit ischemia induced by MCA occlusion [15].

Other Benefits

Preliminary research in animals shows that theanine may have the potential to reduce blood pressure and improve other cardiovascular variables. In rats, theanine can dose-dependently reduce blood pressure [2]. This effect is specific to spontaneously hypertensive rats (rats with naturally high blood pressure), and does not occur in normal rats, in which doses up to 2000 mg/kg have no effect on blood pressure [16]. According to one reference, theanine has been found to reduce cholesterol in both humans and gerbils [17]. In vitro, theanine inhibited copper-induced LDL peroxidation, but the effect was not as strong as that of green tea polyphenols [18].

Theanine has been found to be synergistic with anti-tumor drugs in many studies. Theanine increases the concentration of these drugs in the tumor without altering the concentration in other tissues and also reduces their toxicity to other tissues [6]. Theanine has even been found to inhibit tumor growth by itself in some instances, such as in rats with liver cancer, in which it also reduced cholesterol levels [17]. Drugs with which theanine has been found to be synergistic include doxorubicin (Adriamycin), cisplatin, ironotecan, idarubicin, and pirarubicin [6, 19-21]. It has been tested with success in animals with ovarian cancer and leukemia and in multiple in vitro studies [6, 20]. Theanine may work in this respect by inhibiting the glutamate transporter, which increases the concentration of the drug in the tumor [6]. It has been suggested that drinking green tea may improve the quality of life in cancer patients both by improving the outcomes of therapy and through the positive psychological effects [22].

Another benefit associated with theanine is stimulation of the immune system [23]. Tea drinking has been found to stimulate the immune system in humans, and theanine and related compounds may be the reason. Theanine and its precursor ethylamine can act as antigens, which "prime" T cells and make them more able to respond effectively to challenges to the immune system by pathogens.

The anti-obesity effects of green tea are well known. A recent study identified theanine as one of the ingredients that may contribute to the effect. Rats fed a diet containing theanine for 16 weeks had significantly reduced body weight and intraperitoneal adipose tissue weight as well as reduced serum triglycerides [24].

Theanine also reportedly alleviates some of the symptoms of premenstrual syndrome (PMS) compared to placebo, especially the mental side effects, when used at 200 mg daily [25].

A final use for theanine is to hide the bitter taste of some foods or supplements. Although umami is not a strong taste, it effectively masks bitter tastes, such as the taste of caffeine, ginseng, some antioxidants, and bitter foods [13].

Suggested Use

After oral administration, theanine is absorbed in the intestine and then easily crosses into the brain from the bloodstream through an amino acid transporter [11, 15]. The increase in alpha wave activity in the brain is measurable within 30 minutes and maximized at the 40 minute point [8]. Although the pharmacokinetic profile in humans is not well-known, in rats, it is metabolized in the kidney to L-glutamate and ethylamine and is completely absent 24 hours after administration [1] [26].

No toxic effects of theanine have been reported, and green tea has a long history of safe use [1, 8]. Toxicology studies have failed to find any side effects or toxic effects associated with theanine, even in large amounts. In Japan, it underwent the 28 Day Subacute Toxicity Study, the 78 Week Evaluation of Toxicity and Carcinogenicity, the Acute Toxicity/LD50 Determination, and the Ames Salmonella Mutagenicity tests, and was subsequently approved for unlimited use as a food additive except in infant foods [13]. The LD50 is 5 g/kg [8].

The generally recommended dosage of theanine is 100-200 mg 2-3 times daily or as needed, although some sources recommend even higher doses. It can be used on a regular basis for general stress prevention and good health or saved for periods of high stress. Theanine does not have a strong taste and mixes easily in water.

Referencer:

1. Biochim Biophys Acta. 2003 Mar 17;1620(1-3):47-53. Theanine, gamma-glutamylethylamide, is metabolized by renal phosphate-independent glutaminase. Tsuge H, Sano S, Hayakawa T, Kakuda T, Unno T.

2. Rapid Commun Mass Spectrom. 2004;18(3):251-6. Analysis of derivatized and underivatized theanine enantiomers by high-performance liquid chromatography/atmospheric pressure ionization-mass spectrometry. Desai MJ, Armstrong DW.

3. J Chromatogr A. 2003 Sep 26;1013(1-2):183-9. Rapid analysis of amino acids in Japanese green tea by microchip electrophoresis using plastic microchip and fluorescence detection. Kato M, Gyoten Y, Sakai-Kato K, Toyo'oka T.

4. J Agric Food Chem. 2004 Feb 25;52(4):692-700. Metabolite profiling using (1)H NMR spectroscopy for quality assessment of green tea, Camellia sinensis (L.). Le Gall G, Colquhoun IJ, Defernez M.

5. Chem Senses. 2002 Feb;27(2):105-15. A new specific ageusia: some humans cannot taste L-glutamate. Lugaz O, Pillias AM, Faurion A.

6. Biochim Biophys Acta. 2003 Dec 5;1653(2):47-59. Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents. Sugiyama T, Sadzuka Y.

7. J Agric Food Chem. 1999 Apr;47(4):1593-6. Metabolism of theanine, gamma-glutamylethylamide, in rats. Unno T, Suzuki Y, Kakuda T, Hayakawa T, Tsuge H.

8. Trends in Food Science & Technology. 1999;10(6-7):199-204. L-theanine – a unique amino acid of green tea and its relaxation effect in humans. Lekh Raj Jujena, Chu D, Okubo T, Nagato Y, and Yokogoshi H.

9. Nutrition. 2000 Sep;16(9):776-7. Effect of theanine, r-glutamylethylamide, on brain monoamines, striatal dopamine release and some kinds of behavior in rats. Yokogoshi H, Terashima T.

10. Biosci Biotechnol Biochem. 2000 Feb;64(2):287-93. Inhibiting effects of theanine on caffeine stimulation evaluated by EEG in the rat. Kakuda T, Nozawa A, Unno T, Okamura N, Okai O.

11. Biochem Biophys Res Commun. 2004 Jul 16;320(1):116-22. Possible involvement of group I mGluRs in neuroprotective effect of theanine. Nagasawa K, Aoki H, Yasuda E, Nagai K, Shimohama S, Fujimoto S.

12. Neurochem Res. 1998 May;23(5):667-73. Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Yokogoshi H, Kobayashi M, Mochizuki M, Terashima T.

13. Alternative & Complementary Therapies. 2001 April;7:91-95. 200 mg of Zen: L-theanine boosts alpha waves, promotes alert relaxation. Mason R.

14. Biosci Biotechnol Biochem. 2002 Dec;66(12):2683-6. Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors. Kakuda T, Nozawa A, Sugimoto A, Niino H.

15. Neurosci Lett. 2004 Jun 3;363(1):58-61. Neuroprotective effect of gamma-glutamylethylamide (theanine) on cerebral infarction in mice. Egashira N, Hayakawa K, Mishima K, Kimura H, Iwasaki K, Fujiwara M.

16. Biosci Biotechnol Biochem. 1995 Apr;59(4):615-8. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Yokogoshi H, Kato Y, Sagesaka YM, Takihara-Matsuura T, Kakuda T, Takeuchi N.

17. Biosci Biotechnol Biochem. 2002 Apr;66(4):711-6. Effects of dietary powdered green tea and theanine on tumor growth and endogenous hyperlipidemia in hepatoma-bearing rats. Zhang G, Miura Y, Yagasaki K.

18. Exp Toxicol Pathol. 1997 Dec;49(5):329-35. Influence of green tea and its three major components upon low-density lipoprotein oxidation. Yokozawa T, Dong E.

19. Jpn J Cancer Res. 1999 Jul;90(7):775-80. Membrane transport and antitumor activity of pirarubicin, and comparison with those of doxorubicin. Sugiyama T, Sadzuka Y, Nagasawa K, Ohnishi N, Yokoyama T, Sonobe T.

20. Cancer Lett. 2000 Oct 1;158(2):119-24. Improvement of idarubicin induced antitumor activity and bone marrow suppression by theanine, a component of tea. Sadzuka Y, Sugiyama T, Sonobe T.

21. Cancer Lett. 1998 Nov 13;133(1):19-26. Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma. Sugiyama T, Sadzuka Y.

22. Toxicol Lett. 2000 Apr 3;114(1-3):155-62. Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance. Sadzuka Y, Sugiyama T, Sonobe T.

23. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6009-14. Epub 2003 Apr 28. Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. Kamath AB, Wang L, Das H, Li L, Reinhold VN, Bukowski JF.

24. In Vivo. 2004 Jan-Feb;18(1):55-62. Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. Zheng G, Sayama K, Okubo T, Juneja LR, Oguni I.

25. Institute for Traditional Medicine (www.itmonline.org). Amino Acid Supplements IV: Theanine. Subhuti D. Referencing: Proceedings of the Nogei Kagaku Kai, Bioscience, Biotechnology, and Biochemistry. 2001;75:166. Theanine effects on premenstrual syndrome. Yokogoshi H, et al.

26. Biosci Biotechnol Biochem. 1999 Apr;63(4):615-8. Time-dependent changes of amino acids in the serum, liver, brain and urine of rats administered with theanine. Terashima T, Takido J, Yokogoshi H.

Hvor kan man købe et tilskud af theanin :) ?

Ville jeg meget gerne vide, da det ser MEGET lovende ud :)

[Sqwii]

Det bliver vist også kaldt Suntheanine :o)

[Sqwii]

Desuden kan i læse en ny rapport fra Marts 2007 :) helt ny !

http://www.taiyointernational.com/Download...ne.nutracos.pdf

=)

[Dines]

Det lyder da rigtigt fint alt sammen, men langt det meste af forskningen er på rotter og mus. De fungerer altså ikke altid på samme måde som mennesker. Og den sidste artikel du har smidt ind er det ikke bare en reklame for kosttilskuddet fra et eller andet firma forklædt som et videnskabeligt tidskrift? Hvis du godt vil ha theanine, så er det letteste vel at drikke noget the Det kunne jo ske at der var andre gode stoffer i theen end theanine...

[Keki]

Det lyder liiiidt som endnu en salgstale i stil med den du tidligere har lavet http://www.motion-online.dk/fora/index.php...c=38034&hl=

Correct me if i'm wrong

Edited March 27, 2007 by Keki

[Sqwii]

Det er sandt, men forskningen viser, at det er Theanin i både grøn te og sort te, som har den virkning på kroppen...

Kan godt være, at de fleste er taget på rotter, men det med stress og afslapning ER forsket på mennesker hvor det gav effekt :)

Jeg tror kun at denne aminosyre, vil blive en af fremtidens store tilskud ;o)

Skal lige have penge til at købe det.. så har jeg fundet en dansk side som har dette produkt :)

[Sqwii]

Det lyder liiiidt som endnu en salgstale i stil med den du tidligere har lavet http://www.motion-online.dk/fora/index.php...c=38034&hl=

Correct me if i'm wrong

You are WRONG ;o)

Jeg føler bare du tænker at jeg er en som sidder og laver reklame for produktet, men føler at jeg vil prøve at oplyse en masse danskere om et middel, som har en utrolig gavnlig effekt...

Prøv SELV, at søge om dette middel på nettet og find alle de positive resultater...... :)

[Sortiarius]

Jeg har hørt kefir svamp skulle være godt

[ptpoul]

You are WRONG ;o)

Jeg føler bare du tænker at jeg er en som sidder og laver reklame for produktet, men føler at jeg vil prøve at oplyse en masse danskere om et middel, som har en utrolig gavnlig effekt...

Prøv SELV, at søge om dette middel på nettet og find alle de positive resultater...... :)

Du kan også finde en masse info om hvordan du kan forbedre dit helbred ved at minimere jordstråler.

Der er vist en del info om at forskellige former for te skulle være vældigt sundt. Så drik noget te...

Hvis man ikke kan lide varm te er det let at lave sin egen is te, hvis man bare tilsætter en smule sødemiddel og citron (eller celestial seasonings lemon zinger) får man en lækker sund læskedrik, med moderat koffein indhold.

[Blackmoore]

Grøn the smager godt, er lækkert opkvikkende og har måske en lille fedtforbrændende effekt, så der er allerede gode grunde til at tage sig en kop i ny og næ.

men derfra og til at hoppe direkte på et isoleret element....

[Keki]

You are WRONG ;o)

Jeg føler bare du tænker at jeg er en som sidder og laver reklame for produktet, men føler at jeg vil prøve at oplyse en masse danskere om et middel, som har en utrolig gavnlig effekt...

Prøv SELV, at søge om dette middel på nettet og find alle de positive resultater...... :)

Hmmmmmmmm, det lyder nu lidt som end nu en af dine røverhistorier Hvad hedder din butik?

Kort sagt skal der mere end dine lovprisninger og et par rotteforsøg til at overbevise mig!! - og jeg er ikke alene med min skepsis som du ser! Men kom da med evidens hvis du har det.

Ps. Te ER godt men om det virker "imod".....

Dette skulle være en aminosyre i grøn og sort te, som skal være godt imod:

- Stress

- PMS Symptomer

- Kræft

- Kolesterol (gør det lavere, de dårlige og højere de gode)

- Indlæringsevne og hukommelse

- Fedtforbræning

- Hypertension

- Styrker immunforsvaret markant

.... er vidst at skyde over målet

[Schroinx]

Jeg har hørt kefir svamp skulle være godt

Det har jeg også...

/Schroinx

[Keki]

Jeg har hørt kefir svamp skulle være godt

MEGA GODT!!

KEFIR SVAMP!

[Sqwii]

Hmmmmmmmm, det lyder nu lidt som end nu en af dine røverhistorier Hvad hedder din butik?

Kort sagt skal der mere end dine lovprisninger og et par rotteforsøg til at overbevise mig!! - og jeg er ikke alene med min skepsis som du ser! Men kom da med evidens hvis du har det.

Ps. Te ER godt men om det virker "imod".....

.... er vidst at skyde over målet

Ja.. :o) Men du ka jo tro hvad du vil :)

Kender 1 af mine venner , som har købt L-Theanin, som mærker en markant god virkning og bliver meget mere rolig og ens koncentration bliver øget meget siger han. Derudover føler han sig også mere frisk :)...

Har også selv lige bestilt produktet :)

[Antaeus]

Har hørt og endda læst videnskabelige studier hvor sygdomme fuldstændig forsvandt efter de havde taget et produkt.

Det var et fantastisk produkt som forskerne kaldte Placebo - det virkede mod alt....

Tilbage til emnet - enhver der har tjekket i forskningen ved jo udmærket godt at der ikke er foretaget ret mange gode velkontrollerede humane studier på te og slet ikke på stofferne deri. Man har en god idé om nogle af de virksomme stoffer og standardiserer te i kosttilskud ud fra dem - men at isolere enkeltstofferne og claime effekt er at gå for langt. De humane RCT (randomised clinical trials) skal i hvert fald være til stede.

[qaz]

Ja.. :o) Men du ka jo tro hvad du vil :)

Kender 1 af mine venner , som har købt L-Theanin, som mærker en markant god virkning og bliver meget mere rolig og ens koncentration bliver øget meget siger han. Derudover føler han sig også mere frisk :)...

Har også selv lige bestilt produktet :)

Det er jo lige før det burde være på doping listen, måske.

[OBERSTEN]

Ja.. :o) Men du ka jo tro hvad du vil :)

Kender 1 af mine venner , som har købt L-Theanin, som mærker en markant god virkning og bliver meget mere rolig og ens koncentration bliver øget meget siger han. Derudover føler han sig også mere frisk :)...

Har også selv lige bestilt produktet :)

Du fortsætter bare ufortrødent!

De kender simpelthen 1 af dine venner??! Nu må du sgu liiige!...

Vil vove at påstå at én af dine venner som du kender, som at det er at det er, at der har oplevet øget koncentration, ikke er heeelt nok evidens for en videnskabelig undersøgelse.

Men fantastisk hvis det virker for ham. Giv gerne update hvis han oplever yderligere forbedringer?

Antaeus>> Hvor kan man købe Placebo? Er det oralt eller injekt? Lyder som noget jeg skal afprøve

[Luciferase]

Jeg troede reklame var forbudt herinde. Det er jo ikke første gang trådstarteren har gjort det....

[Blackmoore]

Tænker du da på tråde som denne eller måske denne... eller kunne det være den her eller denne her totale klassiker

[nzme90]

<br />Tænker du da på tråde som <a href="http://www.motion-online.dk/fora/index.php?showtopic=31010&hl=" target="_blank">denne</a> eller måske <a href="http://www.motion-online.dk/fora/index.php?showtopic=30738&hl=" target="_blank">denne</a>... eller kunne det være <a href="http://www.motion-online.dk/fora/index.php?showtopic=31170&hl=" target="_blank">den her</a> eller denne her <a href="http://www.motion-online.dk/fora/index.php?showtopic=32168&hl=" target="_blank">totale klassiker</a><br />

<br /><br /><br />